Mesoscale convective systems (MCSs) frequently occur over Asia during the warm season, often producing intense precipitation with associated socioeconomic impacts. Here we reveal significant trends in MCS occurrence frequency and related precipitation in Asia during the warm season (March–September) in 2001–2020, using a tracking method that combines cloud and precipitation criteria with high-resolution satellite data from the Global Precipitation Measurement mission (GPM). To examine whether there are differences between MCSs of different scales, both MαCSs and MβCSs, with horizontal scales of 200–2000 km and 20–200 km, are tracked. The distribution pattern of frequency and related precipitation of both MαCSs and MβCSs are quite similar and manifest positive trends over East Asia and Northeast Asia, and negative trend over Southeast Asia. The MCS precipitation trend contributes significantly to total precipitation trend, with MαCSs contributing the most. Our analysis indicates the trend in lower-tropospheric water vapor flux convergence has a similar spatial pattern to the MCS frequency and related precipitation trend. Based on an atmospheric moisture flux decomposition analysis, the water vapor flux convergence trend can largely be explained by the change in horizontal wind convergence, while the specific humidity trend driven largely by temperature change plays a minor role. The trend in wind convergence in East Asia and Southeast Asia is possibly related to the evident trend in the lower-tropospheric anticyclone over the western North Pacific and Southeast Asia, which might be due to the relatively stronger warming in the Indian Ocean during the past two decades.