Abstract: Water resources and energy, important subsystems of city, are the basic guarantee for the normal operation of city, which play an important role to brace the urbanization. The interdependence between them are increasing along with the rapid development of China's economy. The relationship between urbanization and consumption of energy and water have become the focal point of the scholars, but the research have more attention to the impact of urbanization on two subsystems separately, and do not reveal the effects of urbanization on the water-energy nexus. Thus, there is little consideration upon the different characteristics of China's several regions in water and energy consumption in urbanization. In this paper, the STIRPAT model is built to reveal the relationship between urbanization and the consumption of water and energy. Also, the influence of urbanization on different main body of water and energy consumption are discussed. The different regional main factors of water and energy in the process of urbanization are identified through water and energy panel data of China's thirty provinces. Finally, through the regression analysis of total water consumption data of agriculture, industry, service industry with total energy consumption data, the relationship of water and energy in the process of urban development are analyzed.