The climate response to biomass burning emissions from the 2019–2020 Australian wildfire season is estimated from two 30-member ensembles using CESM2: one of which incorporates observed wildfire emissions and one that does not. In response to the fires, an increase in biomass aerosol burdens across the southern hemisphere is simulated through late 2019 and early 2020, accompanied by an enhancement of cloud albedo, particularly in the southeastern subtropical Pacific Ocean. In turn, the surface cools, the boundary layer dries, and the moist static energy of the low-level flow into the equatorial Pacific is reduced. In response, the intertropical convergence zone migrates northward and sea surface temperature in the Niño3.4 region cools, with coupled feedbacks amplifying the cooling. A subsequent multiyear ensemble mean cooling of the tropical Pacific is simulated through the end of 2021, suggesting an important contribution to the 2020–2022 strong La Niña events.