This paper describes five sets of regions intended for use in summarizing extreme weather over Earth’s land areas from a climate perspective. The sets differ in terms of their target size: ∼10 Mm2, ∼5 Mm2, ∼2 Mm2, ∼0.5 Mm2, and ∼0.1 Mm2 (where 1 Mm2= 1 million km2). The regions are based on political/economic divisions, and hence are intended to be primarily aligned with geographical domains of decision-making and disaster response rather than other factors such as climatological homogeneity. This paper describes the method for defining these sets of regions; provides the final definitions of the regions; and performs some comparisons across the five sets and other available regional definitions with global land coverage, according to climatological and non-climatological properties.