Previous studies have suggested that the status of the Bering Strait may have a significant influence on global climate variability on centennial, millennial, and even longer time scales. Here we use multiple versions of the National Center for Atmospheric Research (NCAR) Community Climate System Model (CCSM, versions 2 and 3) to investigate the influence of the Bering Strait closure/opening on the Atlantic Meridional Overturning Circulation (AMOC) and global mean climate under present-day, 15 thousand-year before present (kyr BP), and 112 kyr BP climate boundary conditions. Our results show that regardless of the version of the model used or the widely different background climates, the Bering Strait’s closure produces a robust result of a strengthening of the AMOC, and an increase in the northward meridional heat transport in the Atlantic. As a consequence, the climate becomes warmer in the North Atlantic and the surrounding regions, but cooler in the North Pacific, leading to a seesaw-like climate change between these two basins. For the first time it is noted that the absence of the Bering Strait throughflow causes a slower motion of Arctic sea ice, a reduced upper ocean water exchange between the Arctic and North Atlantic, reduced sea ice export and less fresh water in the North Atlantic. These changes contribute positively to the increased upper ocean density there, thus strengthening the AMOC. Potentially these changes in the North Atlantic could have a significant effect on the ice sheets both upstream and downstream in ice age climate, and further influence global sea level changes.