For the 5th IPCC Assessment almost all Earth System Models (ESMs) incorporated new gridded products of land-use and land-use change that were harmonized to ensure a continuous transition from historical to future data in a consistent format for all models. However, these Land-Use Harmonization (LUH) data products are estimates, constrained with data where available, and with modeling assumptions, and the remaining challenge is to quantify, and reduce, the uncertainty in these products. At the same time, satellite remote sensing of the terrestrial biosphere has also evolved. Global-scale land cover extent and change monitoring is now possible given systematically acquired earth observation data sets, advanced characterization algorithms and data intensive computing capabilities. Here we consider: how can satellite remote sensing products be used to generate (and reduce uncertainty in) new gridded maps of land-use transitions for use in coupled carbon-climate simulations? As part of the international effort to develop the next generation of land-use datasets (LUH2), new NASA remote-sensing-based maps of global forest extent and change (Hansen et al. 2013) were used as both an added constraint and diagnostic in the LUH process. Harmonizing this remote sensing data with the LUH data was a major computational challenge involving 143 billion 30m Landsat pixels, and the simulation of over 20 billion LUH unknowns. Our approach involved first harmonizing the definitions of forest loss between the observed and simulated data for the years 2000-2012. Next, new spatial patterns of historical wood harvest were calculated to match the observed forest loss transitions while simultaneously meeting all other constraints of the model, and ensuring consistency throughout the historical time-period. After reconciling definitions and developing new wood harvest patterns the LUH2 global forest loss for the period 2000-2012 was reduced from over 8.3 million km² to 1.78 million km² (compared with the remote-sensing-based forest loss of 2.03 million km²). Next steps are to evaluate the ability of these land-use transitions to improve the representation of land-use-related climate forcings in ESM experiments, and to then build upon the LUH framework to incorporate additional remote-sensing data constraints.