Tropical basin interaction and the interaction between mid-high latitudes and the tropics are areas of active research. Given the importance of the interactions between different tropical ocean basins and the interactions between the AMV and tropics, and the relationship between AMOC and AMV under our changing climate, it is our intention to review the current understanding of these relationships and the underlying physical processes governing these relationships. In this review, we assess the current understanding of tropical variability and the interactions between tropics and extratropics, including the ENSO variability and diversity, influence of ENSO on the tropical Atlantic and Indian oceans, interactions of tropical basins on different timescales, AMOC variability, relationship between AMOC and AMV, influence of AMOC on ENSO and tropical variability, and the influence of other mid-high latitude processes on the tropical variability. In general, although ENSO is the most important mode of variability on interannual timescales, the characteristics of ENSO itself are not stationary and may be influenced by a number of factors ranging from different tropical basins to mid-high latitude processes. The strength and variations of these interactions among different tropical basins and different latitudes can be modulated by changes in external forcings from natural or anthropogenic origins and may also be affected by the nonlinear interactions among different internal variability.