Characterization and effective management of fuel quality and quantity at the landscape scale is essential for quantifying, managing and reducing wildfire exposure and risk. Prescribed treatments manipulate and manage live or dead vegetation to alter the structure and composition of fuels, which creates a more fire resilient ecosystem and protects critical infrastructure and lives. Treatments often include prescribed fire and mechanical thinning to reduce fuel loads in a controlled and designed fashion. The shape, extent, and placement of treatments determine their effectiveness in reducing wildfire risk to communities, infrastructure and assets. Fuel treatment designs must also be informed by equally important social, economic, political and human health concerns held by many stakeholder groups, who are often in conflict with each other. We used the LANDFIRE 40 Scott and Burgan Fire Behavior Fuel Model (FBFM40) to identify and characterize contiguous and connected core fuel patches across the Sierra-Nevada region of California. Using FIRE-PATH, a landscape scale fuel connectivity model, we conducted a large ensemble of simulations to quantify the connectivity of fuels on the landscape. FIRE-PATH simulates the movement of fire started randomly at one of the fuel patches as it moves across the fuel landscape and connects to other patches. The movement of fire through the fuel landscape is stochastic and is influenced by fuel quality. Successful connections between fuel patches, aggregated over thousands of simulations, provide a quantification of the likelihood and frequency of fire pass-through and fire exposure risk at each location on the landscape. The resulting fuel connectivity map shows funneling channels, bottlenecks and intersections for wildfire movement on the landscape. Placing treatments in the highest throughput fuel connectivity areas, up to the total acreage that can be installed, ensures their maximum effectiveness and provides an optimized treatment design for this multi-state fuel landscape. We also quantify the social, economic and biodiversity implications of fire on the landscape and design fuel treatment scenarios that forest and fire managers can use to effectively manage the national wildfire crisis.